The medical condition Hyperkalemia occurs due to excess potassium in your blood. Potassium aids your nerves and muscles, including your heart, to function properly. However, excess of potassium in the blood can be dangerous and can cause severe heart problems. It can result from malfunctioning of the kidneys, consuming high potassium diet, disorders like Addison’s disease or due to burns, other serious injuries, and poorly managed diabetes. CBD can help with hyperkalemia by improving the functioning of your nerves and muscle weakness, apart from benefitting the heart and can also assist in kidney disorders.
What Constitutes Hyperkalemia
Hyperkalemia signifies an excessive potassium level within the bloodstream. Various important functions are performed by potassium in the body. Potassium is vital for the proper working of the heart, muscles, and nerves.
Potassium aids the body control the action of the muscle, like the smooth muscle or involuntary muscles, like the muscles present in the digestive tract, and skeletal muscle or voluntary muscles, like muscles of the torso and extremities, and the heart muscles.
It is even essential for keeping up the normal electrical rhythm of the heart and for regular electrical signals within the nervous system.
The normal level of potassium within the blood comprises 3.5-5.0 milliEquivalents each liter (mEq/L). Potassium levels between 5.1mEq/L and 6.0 mEq/L are regarded as mild hyperkalemia. Potassium levels from 6.1mEq/L to 7.0 mEq/L comprise moderate hyperkalemia, while levels over 7 mEq/L indicate severe hyperkalemia.
Causes Of Hyperkalemia
Often a report about high blood potassium doesn’t reflect true hyperkalemia. Rather, it may result from the rupture of blood cells within the blood sample during or shortly following the drawing of blood.
The most common reason for truly high potassium (hyperkalemia) is associated with your kidneys, like:
- Chronic kidney disease
- Acute kidney failure
Other causes of hyperkalemia comprise:
- Addison’s disease (adrenal inadequacy)
- Angiotensin II receptor blockers
- Angiotensin-transforming enzyme (ACE) inhibitors
- Excessive use of potassium supplements
- Death of red blood cells on account of serious injury or burns
- Type 1 diabetes
Symptoms Of Hyperkalemia
The symptoms of hyperkalemia depending on the level of the mineral within your blood. You may not experience any symptoms at all. But if your potassium levels are sufficiently raised to cause symptoms, you may experience:
- Tiredness or weakness
- Nausea or vomiting
- A perception of numbness or tingling
- Trouble breathing
- Palpitations or irregular heartbeats
- Chest pain
In severe cases, high potassium can lead to paralysis or heart failure. In the absence of treatment, high potassium levels can make your heart stop.
How CBD Is Effective For Hyperkalemia
The vasodilatory, analgesic, antiemetic, and anxiolytic properties of CBD help it to manage the symptoms of Hyperkalemia.
Regulates Release Of Chemicals
CBD possesses the capacity to impaction channels, which regulate the discharge of chemicals such as sodium, calcium, and potassium. Thereby, CBD enables it to regulate potassium levels during hyperkalemia.
Helps To Alleviate Pain
CBD includes the capacity to regulate not just acute pain and chronic pain but also intractable pain. It can also regulate neuropathic pain, a kind of pain that is poorly controlled with conventional painkillers such as Opioids.
CBD activates the vanilloid receptors, also known as TRPV1 receptor to improve their function. Vanilloid receptors have also been termed capsaicin receptors as the way they regulate pain resembles that of the skin irritant capsaicin.
CBD activates the vanilloid receptors to promote faster desensitization. CBD turns these receptors lead to pain.
Anandamide, an endogenous cannabinoid produced by the body, confers analgesic properties upon activating CB1 receptor. However, this major endocannabinoid gets easily split through an enzyme known as fatty acid amide hydrolase or FAAH, therefore, its therapeutic impact doesn’t stay long. CBD aids anandamide remains longer within the body by hooking up a ride with transport protein of anandamide known as fatty acid- binding protein or FABP.
The FABP comprises what imparts anandamide to the enzyme that downgrades it, while CBD actively competes with anandamide for attaching with the FABP. Having lesser FABP to join, anandamide remains within your body longer and not get disintegrated.
There are several types of serotonin or 5-HT receptors and they regulate different physiological reactions. The receptor that is involved in pain regulation comprises the 5-HT1A serotonin receptors. Cannabidiol activates these receptors, improves their impact, and offers alleviation from pain.
Lessens Vomiting And Nausea
Vomiting and nausea are symptoms of the medical condition involving hyperkalemia.
CBD can lower these symptoms in different ways.
The discharge of serotonin with its impact upon the gastrointestinal tract activates vomiting and nausea. Serotonin activates these symptoms within the brain when it activates the serotonin receptors within vomiting and nausea regulatory center of the brain.
CBD activates the dorsal raphe nucleus to generate its anti-vomiting and anti-nausea effects by lowering its discharge of serotonin.
Anandamide, on stimulating CB1 receptors, generates antiemetic effects. And CBD may improve the anandamide level within the brain by aiding to stop its degradation. This makes you realize the real importance of CBD’s prevention of degradation of anandamide. CBD retains anandamide in your body longer for you to reap the advantages of the endocannabinoid created by your own body.
Improves The Cardiovascular System
CBD acts upon the cardiovascular in two ways: it relaxes the blood vessels itself, and it aids to enhance the action of compounds that lower blood pressure and slowly clear blockages. Various other studies, performed on humans as well as rats that display CBD to generate vasorelaxation by a receptor situated in the endothelium (the inner layer of cells covering your blood vessels). Researchers found proof that CBD acts on a receptor in the endothelium to aid relax and expand blood vessels.
The anxiolytic (anti-anxiety) effects of CBD can also benefit cardiovascular health by reducing cardiac response to stress, lowering the probability of an abrupt cardiac event, such as a heart attack. CBD can aid regulate an irregular heartbeat, further lessening your risk of heart attack, as in hyperkalemia. These studies indicate that CBD casts a regulatory effect on heart rate, and it does not seem to elevate heart rate.
Conclusion On CBD For Hyperkalemia
CBD works as an adjunct therapy in containing hyperkalemia, and its effect on the kidney and manages its overall symptoms. This plant molecule has shown encouraging results as an anti-inflammatory, analgesic, antibiotic, antiemetic, anticonvulsant, antispasmodic and vasodilator. Thus, CBD offers relief in the life-threatening condition of severe hyperkalemia, as well as a host of other medical conditions.